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KMID : 0624620080410090640
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BMB Reports
2008 Volume.41 No. 9 p.640 ~ p.644
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An anti-viral peptide derived from the preS1 surface protein of hepatitis B virus
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Kim Do-Hyoung
Ni Yi
Lee Si-Hyung
Urban Stephan
Han Kyou-Hoon
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Abstract
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The preS1 surface protein of the hepatitis B virus (HBV) is a key factor involved in initial viral entry into hepatocytes. It has been long postulated that an anti-HBV effect should be achievable using peptide fragments of the preS1. Recent reports demonstrated that several preS1-derived lipo-peptides in genotype D HBV exhibit nano to picomolar inhibitory activity against HBV infection. In this study, an acylated analog of a preS1 fragment, a 21-residue lipo-peptide (named 7524 BVS7) with a sequence of palmitoyl-GMGTNLSVPNPLGFFPDHQLDC-NH2, from genotype C HBV was produced base upon a previous structural study and was shown potently inhibits HBV infection with an IC50 of ≒ 20 nM.
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KEYWORD
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Hepatitis B virus (HBV), Intrinsically unstructured protein (IUP), Lipo-peptides, Local pre-structured motif, Nuclear magnetic resonance (Nmr), preS1
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